Infection of SARS-CoV on juvenile and adult Brandt's voleMicrotus brandtii.
Identifieur interne : 004788 ( Main/Exploration ); précédent : 004787; suivant : 004789Infection of SARS-CoV on juvenile and adult Brandt's voleMicrotus brandtii.
Auteurs : Hong Gao [République populaire de Chine] ; Jingpian Peng [République populaire de Chine] ; Wei Deng [République populaire de Chine] ; Dazhao Shi [République populaire de Chine] ; Linlin Bao [République populaire de Chine] ; Dehua Wang [République populaire de Chine] ; Binglin Zhang [République populaire de Chine] ; Chuan Qin [République populaire de Chine] ; Zhibin Zhang [République populaire de Chine]Source :
- Chinese science bulletin = Kexue tongbao [ 1001-6538 ] ; 2005.
Abstract
We studied the infectious effect of SARS-CoV virus on juvenile and adult Brandt's Vole (Microtus brandtii) by nasal cavity spraying method (CCID50 is 105.7). SARS virus caused serious deaths in adults. The death adults demonstrated hemorrhage from mouth, nasal cavity and intestine, hemorrhageious interstitial pneumonia and gore in liver, spleen and kidney. The survival adults demonstrated local hemorrhagic spot in lung and emphysema, but the other organs showed no pathological abnormality. SARS virus caused no deaths in juveniles, but locomotion of infected juveniles became slower. In the early stage, there was local pneumonia in lung and SARS viruses were isolated from the pathological tissue. Only one control juvenile lived and the infected juvenile showed local pneumonia in lung. The results demonstrated that SARS-CoV infected Brandt's vole seriously and adults were more susceptive to SARS-CoV than juveniles. The Brandt's vole may be a potential animal model for SARS research.
DOI: 10.1007/BF03183693
PubMed: 32214720
Affiliations:
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Animals Science, Chinese Academy of Medical Sciences & Peking Union Medical College, 100021 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Dehua" sort="Wang, Dehua" uniqKey="Wang D" first="Dehua" last="Wang">Dehua Wang</name><affiliation wicri:level="1"><nlm:affiliation>2State Key Laboratory of Integrated Management on Pest Insects and Rodents, State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100080 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>2State Key Laboratory of Integrated Management on Pest Insects and Rodents, State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100080 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Binglin" sort="Zhang, Binglin" uniqKey="Zhang B" first="Binglin" last="Zhang">Binglin Zhang</name><affiliation wicri:level="1"><nlm:affiliation>1Institute of Laboratory Animals Science, Chinese Academy of Medical Sciences & Peking Union Medical College, 100021 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Institute of Laboratory Animals Science, Chinese Academy of Medical Sciences & Peking Union Medical College, 100021 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><affiliation wicri:level="1"><nlm:affiliation>1Institute of Laboratory Animals Science, Chinese Academy of Medical Sciences & Peking Union Medical College, 100021 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Institute of Laboratory Animals Science, Chinese Academy of Medical Sciences & Peking Union Medical College, 100021 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Zhibin" sort="Zhang, Zhibin" uniqKey="Zhang Z" first="Zhibin" last="Zhang">Zhibin Zhang</name><affiliation wicri:level="1"><nlm:affiliation>2State Key Laboratory of Integrated Management on Pest Insects and Rodents, State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100080 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>2State Key Laboratory of Integrated Management on Pest Insects and Rodents, State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100080 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">Chinese science bulletin = Kexue tongbao</title><idno type="ISSN">1001-6538</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied the infectious effect of SARS-CoV virus on juvenile and adult Brandt's Vole (Microtus brandtii) by nasal cavity spraying method (CCID<sub>50</sub> is 10<sup>5.7</sup>). SARS virus caused serious deaths in adults. The death adults demonstrated hemorrhage from mouth, nasal cavity and intestine, hemorrhageious interstitial pneumonia and gore in liver, spleen and kidney. The survival adults demonstrated local hemorrhagic spot in lung and emphysema, but the other organs showed no pathological abnormality. SARS virus caused no deaths in juveniles, but locomotion of infected juveniles became slower. In the early stage, there was local pneumonia in lung and SARS viruses were isolated from the pathological tissue. Only one control juvenile lived and the infected juvenile showed local pneumonia in lung. The results demonstrated that SARS-CoV infected Brandt's vole seriously and adults were more susceptive to SARS-CoV than juveniles. The Brandt's vole may be a potential animal model for SARS research.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Gao, Hong" sort="Gao, Hong" uniqKey="Gao H" first="Hong" last="Gao">Hong Gao</name></noRegion><name sortKey="Bao, Linlin" sort="Bao, Linlin" uniqKey="Bao L" first="Linlin" last="Bao">Linlin Bao</name><name sortKey="Deng, Wei" sort="Deng, Wei" uniqKey="Deng W" first="Wei" last="Deng">Wei Deng</name><name sortKey="Peng, Jingpian" sort="Peng, Jingpian" uniqKey="Peng J" first="Jingpian" last="Peng">Jingpian Peng</name><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><name sortKey="Shi, Dazhao" sort="Shi, Dazhao" uniqKey="Shi D" first="Dazhao" last="Shi">Dazhao Shi</name><name sortKey="Wang, Dehua" sort="Wang, Dehua" uniqKey="Wang D" first="Dehua" last="Wang">Dehua Wang</name><name sortKey="Zhang, Binglin" sort="Zhang, Binglin" uniqKey="Zhang B" first="Binglin" last="Zhang">Binglin Zhang</name><name sortKey="Zhang, Zhibin" sort="Zhang, Zhibin" uniqKey="Zhang Z" first="Zhibin" last="Zhang">Zhibin Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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